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The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients
Rheumatology International, 10/28/09

AuthorLastNameFI et al. – Objective of the study is to assess the effects of adalimumab and MTX therapy on peripheral Th17 cells and IL-17/IL-6 secretion in RA patients. Adalimumab and MTX treatment down regulates peripheral Th17 cells and serum IL-6 level in RA patients. Baseline Th17 level negatively predicts the effect of adalimumb/MTX treatment

• 20 active RA patients were treated with oral MTX 15 mg per week , or hypodermal adalimumab 40 or 80 mg every other week
• Peripheral blood samples taken for laboratory evaluation at week 0 and week 12 of treatment, including flowcytometric detection of peripheral CD4(+) IL-17(+) cells, RT-PCR detection of mRNA expressions of IL-17, RORc and FoxP3, and ELISA determination of serum IL-17 and IL-6
• 10 age and sex marched healthy volunteers included as normal controls
• Results showed that (1) DAS28 in both groups improved at week 12 compared to week 0

• Results showed that (1) DAS28 in both groups improved at week 12 compared to week 0
• 2) The percentage and MFI of peripheral CD4(+) IL-17(+) cells in RA patients were significantly higher comparing to normal controls (1.64 ± 0.97% vs. 0.75 ± 0.20%, p < 0.01; and 29.8 ± 9.7 vs. 19.8 ± 4.6, and positively correlated with ESR and DAS28
• Peripheral Th17 cells and serum IL-6 in RA patients decreased after treatment
• Peripheral FoxP3 mRNA expression in active RA patients was significantly lower comparing to normal controls, and negatively correlated with ESR
• Peripheral Th17 cells and serum IL-6 in RA patients decreased after treatment
• Peripheral FoxP3 mRNA expression in active RA patients was significantly lower comparing to normal controls, and negatively correlated with ESR
• Baseline Th17 percentage of RA patients negatively correlated with DAS28 improvement after treatment

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