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Mannose binding lectin levels are not related to radiographic damage in ankylosing spondylitis
Rheumatology International, 10/27/09

Aydin SZ et al. – In the current study the goal was to investigate the effect of MBL deficiency in radiographic damage of the spine in a large group of AS patients. It is concluded that MBL deficiency prevalence is not increased in AS patients and it is not a cause of a severe radiographic damage.

Methods

191 AS patients and 85 healthy controls studied
Disease activity, radiological scores, and demographic features recorded
MBL levels measured with standard ELISA kits

Results

Results showed that median MBL levels in AS and healthy controls were 2,530 (range 0–5,861) ng/ml and 3,415 (0–7,950) ng/ml, respectively
Disease activity, clinical picture, and therapies not associated with MBL levels
Both BASRI and mSASSS scores found similar in AS patients with or without MBL deficiency

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