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See Latest ArticlesDiagnostic value of synovial fluid anti-cyclic citrullinated peptide antibody for rheumatoid arthritis
Rheumatology International, 10/21/09
Heidari B et al. – Findings of this sudy indicate that sf-CCP yields diagnostic ability as comparable as sm-CCP for RA. Respecting to local production of sf-CCP prior to disease onset, therefore sf-CCP determination may offer earlier as well as additional diagnostic information which may be more helpful in recognizing RA particularly among recent onset arthritis.
Methods- 128 patients consisted of 37 RA confirmed by American College of Rheumatology revised criteria, 91 non-RA (50 non-RA inflammatory arthritis and 41 osteoarthritis) entered study
- Serum anti-CCP (sm-CCP) and Sf-CCP measured by ELISA method
- Receiver operating characteristics curves constructed to determine the optimal cutoff point levels for sf-CCP and sm-CCP to discriminate RA from non-RA
- Diagnostic characteristics of both variables determined by comparison of RA patients with non-RA controls
- Mean levels of sf-CCP and sm-CCP significantly higher in RA than in non-RA
- Sf-CCP discriminated RA from non-RA at optimal cutoff value of 10 U/mL with high accuracy at AUC value of 0.897 ± 0.039 sensitivity of 83.7% and specificity of 95.6%
- Sm-CCP diagnosed RA at optimal cutoff level of 14.6 U/mL with respective sensitivity, specificity and AUC values of 84.8, 94.3% and 0.895 ± 0.049)
- Sm-CCP strongly correlated with sf-CCP
- Two of 5 sm-CCP negative RA and 25.7% of serum rheumatoid factors negative RA were sf-CCP positive
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Treatment of polymyalgia rheumatica
Archives of Internal Medicine, 11/10/09
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor [alpha] therapies: Does the risk change with the time since start of treatment?
Arthritis & Rheumatism, 11/05/09
Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
Arthritis Care and Research , 11/03/09
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