Rheumatology

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Health-related quality of life (Nottingham Health Profile) in knee osteoarthritis: Correlation with clinical variables and self-reported disability
Rheumatology International, 10/21/09

Yildiz N et al. – This study concludes that patients with knee osteoarthritis undergo a significant impact on multiple dimensions of HRQoL, compared with healthy controls. The NHP is related to the clinical status and functional ability of patients with knee OA, and it can be used as a sensitive health status measure for clinical evaluation.

• 140 patients with knee OA (104 female, 36 male, mean age 59.39 ± 7.62 years, mean disease duration 58.56 ± 56.78 months) and 40 sex and age-matched controls were included in the study.
• HRQoL, disability and pain assessed using NHP, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS), respectively

• Results showed that 6 subgroups of NHP revealed higher scores in the knee OA patients compared with controls
• All subgroups of NHP significantly correlated to VAS-rest, VAS-activity, 15-m walk test and WOMAC scores
• Knee flexion or restricted extension range of motion was significantly correlated with pain, energy and physical mobility subgroups of the NHP
• Statistically significant correlations between NHP pain, emotional reaction, and physical mobility subgroup scores and BMI
• No correlations between all NHP scores and duration of disease

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