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Antibodies to human tissue transglutaminase and alterations of vitamin D metabolism in ankylosing spondylitis and psoriatic arthritis
Rheumatology International, 10/20/09

Teichmann J et al. – A positive htTG status entails the risk of a bad vitamin D supply, which should be considered in young patients since this constellation favors a reduction in bone density. The coincidence of ASP along with detection of htTG and clinically asymptomatic celiac disease as an accessory source of inflammation with a negative influence on the bone metabolism is also conceivable. Clinicians need to be aware of patients younger than 45 years with ASP, which have important implications for the correct treatment and vitamin D supplementation.

Methods

Cross-sectional study
Evaluated both biochemical markers of bone turnover, BMD and htTG in 76 patients with ASP and 120 patients with PsA
Significantly higher prevalence of htTG was detected only in ASP (14/76). ASP patients with negative htTG status

Results

Reduction of BMD in lumbar spine determined both in ASP (42.7%) and in PsA (57.3%)
Significantly higher prevalence of htTG detected only in ASP (14/76)
ASP patients with negative htTG status have significant higher 25-vitamin D3 levels
ASP patients with positive htTG status are younger
A positive htTG status entails risk of bad vitamin D supply, which should be considered in young patients since this constellation favors a reduction in bone density

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