Rheumatology

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Low prevalence of hepatitis B virus infection in patients with systemic lupus erythematosus in southern China
Rheumatology International, 10/21/09

Zhao J et al. – To investigate the prevalence of hepatitis B virus (HBV) infection in systemic lupus erythematosus (SLE) patients in southern China, SLE inpatients were retrospectively investigated for their HBV infection rate.The prevalence of HBV infection in SLE patients was lower than that in sex- and age-matched non-SLE controls in southern China. The characteristic IFN signatures in SLE may favor the subsequent clearance of HBV.

• SLE inpatients retrospectively investigated for their HBV infection rate
• 15 SLE patients positive for HBsAg followed up
• Serum interferon (IFN)- &alpha levels among SLE patients detected by ELISA

• Results showed estimated HBsAg-positive rate 10.74% in general population
• HBsAg-positive rate lower in SLE patients compared with controls (2.33 vs. 9.57%)
• 13 out of 15 SLE patients converted from HBsAg positive to HBV surface antibody (HBsAb) positive even under glucocorticoid therapy
• Significantly increased IFN-&alpha levels in SLE patients

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