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See Latest ArticlesScoring evaluation for histopathological features of synovium in patients with rheumatoid arthritis during anti-tumor necrosis factor therapy
Rheumatology International, 10/21/09
Yamanaka H et al. – There were no significant differences in total score between anti-TNF? and no anti-TNF? groups. However, significant differences were observed in scores of synoviocyte hyperplasia and perivascular infiltrates of lymphocytes between the groups. These results suggested that these agents have a suppressive effect on cell proliferation in the lining layer and on perivascular lymphocyte infiltration.
Methods- Synovial tissue specimens obtained during total knee arthroplasty (TKA) from 42 RA patients (12 men, 30 women)
- 21 patients were given anti-TNF &alpha (infliximab, n = 12; etanercept, n = 9), while the remaining 21 RA patients were given no such agents
- Histopathological findings compared between specimens from these groups using the histological scoring system reported by Rooney, which consists of 6 items: degree of synovial hyperplasia, fibrosis, number of blood vessels, perivascular lymphocyte infiltration, focal aggregates of lymphocytes, and diffuse infiltrates of lymphocytes
- Clinical laboratory data including CRP, matrix metalloproteinase-3 (MMP-3), and disease activity scores including 28-joint count (DAS28), disease duration, MTX dose, and glucocorticoid dose also assessed before surgery
- No significant differences in total score between anti-TNF? and no anti-TNF &alpha groups
- Significant differences were observed in scores of synoviocyte hyperplasia and perivascular infiltrates of lymphocytes between the groups
Today in Clinical Pharmacology...keeping you current
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Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09
Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid
Osteoporosis International, 11/25/09
Today in Rheumatoid Arthritis...keeping you current
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CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
Arthritis Research & Therapy, 11/25/09
Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis
Annals of Rheumatic Diseases, 11/24/09
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis
Annals of Rheumatic Diseases, 11/23/09
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