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Increased levels of circulating microparticles in primary Sjogrens syndrome, systemic lupus erythematosus and rheumatoid arthritis, and relation with disease activity
Arthritis Research & Therapy, 10/20/09

Sellam J et al. – Plasma MP level is elevated in pSS, as well as in SLE and RA, and could be used as a biomarker reflecting systemic cell activation. Level of leukocyte-derived MPs is increased in pSS only. The MP level is low in case of more severe AID, probably because of high secretory phospholipase A2 (sPLA2) activity, which leads to consumption of MPs. Increase of platelet-derived MPs, sCD40L and sCD62P, highlights platelet activation in pSS.

Methods

Measured plasma levels of total, platelet and leukocyte MPs by prothrombinase capture assay and flow cytometry in 43 patients with pSS, 20 with SLE and 24 with RA (HCs
44 healthy controls
Secretory phospholipase A2 (sPLA2) activity assessed by fluorometry
Soluble CD40 ligand (sCD40L) and soluble P-selectin (sCD62P), reflecting platelet activation, measured by ELISA

Results

Patients with pSS showed increased plasma level of total MPs , as did patients with RA and SLE , as compared with HCs
Patients with AIDs all showed increased levels of platelet MPs
Only those with pSS showed increased levels of leukocyte MPs
Results by capture assay and flow cytometry correlated
In patients with high disease activity according to extra-glandular complications (pSS), DAS28 (RA) or SLEDAI (SLE) compared with low-activity patients, the MP level only slightly increased in comparison with those having low disease activity
Platelet MP level inversely correlated with anti-DNA antibody level in SLE and serum beta-2 microglobulin level in pSS
Levels of total and platelet MPs inversely correlated with sPLA2 activity
sCD40L and sCD62P concentrations significantly higher in pSS than in HC

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