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See Latest ArticlesMalnutrition is common in systemic sclerosis: results from the Canadian Scleroderma Research Group database
Journal of Rheumatology, 10/19/09
AuthorLastNameFI et al. – Systemic sclerosis (SSc) is a multisystem disease associated with significant morbidity and increased mortality. The risk for malnutrition in SSc is moderate and is associated with shorter disease duration, markers of GI involvement, and disease severity. Patients with SSc should be screened for malnutrition, and potential underlying causes assessed and treated when possible.
Methods- Cross-sectional multicenter study
- 586 patients from Canadian Scleroderma Research Group Registry
- Assessed with detailed clinical histories, medical examinations, and self-administered questionnaires
- Primary outcome was risk for malnutrition using “malnutrition universal screening tool” (MUST)
- Multiple logistic regression used to assess relationship between selected demographic and clinical variables and MUST categories
- Of 586 patients in study, MUST scores revealed almost 18% at high risk for malnutrition
- Significant correlates of high malnutrition risk included number of GI complaints, disease duration, diffuse disease, physician global assessment of disease severity, hemoglobin, oral aperture, abdominal distension on physical examination, and physician-assessed possible malabsorption
- Among 14 GI symptoms, only poor appetite and lack of history of abdominal swelling and bloating predict MUST
- These factors accounted for 24% of variance in MUST scores
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Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
Journal of Rheumatology, 11/20/09
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Clinical Rheumatology, 11/19/09
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