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Aggarwal R et al. – Elevated cTnT, but not cTnI, was highly associated with CK in patients with IIM despite the absence of myocardial ischemia.

Methods

Retrospective study
Patients with IIM followed by rheumatology service of county hospital from 2004 to 2008
Patients with myocardial ischemia and/or with renal failure excluded
Clinical data including electromyogram, muscle biopsy, and CK, cTnT and cTnI recorded
Patients with simultaneous analysis of CK and cardiac troponin (cTnT or cTnI) levels studied
CK levels correlated with cTnT and cTnI by chi-square test and Spearman correlation

Results

49 patients with IIM (69 observations) who satisfied our inclusion criteria identified
Primary diagnosis polymyositis in 23, dermatomyositis in 16, and myositis associated with connective tissue disease in 10 patients
33/49 women with average age 45.8 y
28 patients with IIM had simultaneous CK and cTnT values assayed
18/23 patients with elevated CK had elevated cTnT, and 5/5 patients with normal CK levels had normal cTnT levels
In 41 patients with IIM who had simultaneous CK and cTnI levels assayed, only 1/29 with elevated CK had elevated cTnI, and 12/12 patients with normal CK had normal cTnI
CK correlated strongly with cTnT but did not correlate with cTnI

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