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Serum amyloid A and C-reactive protein concentrations are differently associated with markers of autoimmunity in patients with primary Sjogren's syndrome
Journal of Rheumatology, 10/19/09

Pertovaara M et al. – Primary Sjögren’s syndrome (pSS) is an autoimmune disease in which the concentration of the acute-phase protein serum C-reactive protein (CRP) is low. We investigated whether levels of another acute-phase protein, serum amyloid A (SAA), are increased in patients with pSS and whether the immunological markers in patients with pSS are associated with variation in SAA levels. Results imply that high SAA production could constitute a protective element in pSS: high SAA levels inhibit in particular various signs of B cell hyperreactivity, i.e., IgG and autoantibody production

Methods

Serum SAA concentrations measured by ELISA in 74 patients with pSS and 56 control subjects with sicca symptoms

Results

Median SAA levels did not differ significantly between patients with pSS and subjects with sicca symptoms
In pSS SAA concentrations correlated significantly with age, leukocyte count, CRP, interleukin 6, and C4
Unlike CRP, there was significant inverse correlation between SAA and serum IgG levels and anti-SSA antibody titers, as well as trend towards inverse correlation between SAA and antinuclear antibody and rheumatoid factor titers

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