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Developments in the scientific understanding of rheumatoid arthritis
Arthritis Research & Therapy, 10/28/09
Goronzy JJ et al. – Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes preclinical systemic abnormalities and eventually leads to synovial inflammation and destruction of the joint architecture.The end result of RA, destruction of cartilage and bone, appears to be driven by cytokine– and cell contact–induced activation of synoviocytes and monocytic cells, some of which differentiate into tissue–destructive osteoclasts. Targeting mediators involved in this process has greatly improved the management of this chronic inflammatory syndrome.
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Today in Autoimmune/Heritable...keeping you current
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Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjogrens syndrome
Annals of Rheumatic Diseases, 11/23/09
Genetic background of systemic sclerosis: autoimmune genes take centre stage
Rheumatology, 11/23/09
Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity
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Today in Rheumatoid Arthritis...keeping you current
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Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis
Annals of Rheumatic Diseases, 11/24/09
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis
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