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Comparison of argon laser photocoagulation-induced cutaneous inflammation and skin pathergy test in Behçets disease
Clinical Rheumatology, 10/15/09

Sayarlioglu M et al. – The preliminary results of this study reveal that ALP can induce a skin hyperreactivity similar to the needle prick-induced SPR in patients with BD. It was shown that ALP can induce skin inflammation with its thermal effect and without any inoculation of antigen in BD. This method would help to develop another experimental method to investigate the cutaneous inflammation in BD.

• Study group consisted of 35 patients with BD and 28 healthy volunteers
• The ALP applied to left forearms of all cases from 20-cm distance (2,000 mW, 100 µm) with exposure times ranging from 0.2 to 0.7 s with 0.1-s increments
• SPT with 3 prics performed to both forearms of all cases
• ALP-induced cutaneous inflammation and SPT evaluated and scored with same method at 48 h, and SPR scores of 2+ and above accepted as positive

• Positive results found in 8 cases (23%) with the ALP and in 9 (26%) with SPT in patients with BD
• No clear correlation between ALP and SPT results and also between exposure time to laser beam and SPR scores

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