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Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
Arthritis Research & Therapy, 10/14/09

Yang H et al. – The aim of this study was to explore the nature of abnormally increased CD4+CD25-Foxp3+ T cells in UNOL patients. CD4+CD25-Foxp3+ T cells in UNOL patients are different from regulatory T cells, both phenotypically and functionally. CD127 is not an appropriate surface marker for intracellular Foxp3 in CD4+CD25- T cells.

Methods

The expressions of surface (CD4, CD25, CD127, chemokine receptor 4 (CCR4), glucocorticoid induced tumor necrosis factor receptor (GITR) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)) and intracellular molecules (Foxp3), as well as cytokine synthesis of peripheral blood mononuclear cells from twenty-two UNOL patients were analyzed by flow cytometry
Proliferative and suppressive capacities of different T cell subgroups from UNOL patients also assessed

Results

In UNOL patients, percentages of CD127low/- in CD25high, CD25low and CD25- subpopulations of CD4+Foxp3+ T cells were 93.79+/-3.48%, 93.66+/-2.31% and 91.98+/-2.14% respectively , whereas, the expressions of Foxp3 showed significant differences in CD25high (91.38+/-2.57%), CD25low (71.89+/-3.31%), and CD25- (9.02+/-2.21%) subpopulations of CD4+CD127low/- T cells
Expressions of surface CCR4, GITR and CTLA-4 on CD4+CD25-Foxp3+ T cells significantly less than CD4+CD25+Foxp3+ T cells
Moreover, different from CD4+CD25+Foxp3+ T cells, CD4+CD25-Foxp3+ T cells also synthesized interferon-gamma (IFN-gamma) interleukin (IL)-4IL-2 and IL-17(P<0.05), although less than CD4+CD25+Foxp3-T cells. The suppressive capacity most prominent in CD4+CD25highCD127low/-, followed by CD4+CD25lowCD127low/-
CD4+CD25-CD127- T cells showed least suppressive capacity which was similar to effector T cells

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