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Terminal monosaccharide screening of synovial immunoglobulins G and A for the early detection of rheumatoid arthritis
Rheumatology International, 10/13/09

Kratz EM et al. – The proportions of the sialyl and fucosyl determinants of intact synovial A and G immunoglobulins were clearly lower in the early RA group than in the advanced. The analysis of terminal oligosaccharide exposition in IgG, IgG fragments, and IgA present in the synovial fluid of RA patients might be applicable as a stage-specific marker in the diagnosis and therapy of RA patients

• Expressions of some terminal glycotopes of synovial immunoglobulins G, A, and M analysed in relation to RA progression defined according to early and advanced radiological changes in patients’ hands
• The relative amounts of terminal monosaccharides determined by lectin-immunoblotting of immunoglobulin preparations using appropriate lectins able to recognize ?2,6-linked (Sambucus nigra agglutinin) and &alpha 2,3-linked (Maackia amurensis agglutinin) sialic acid, galactose (Ricinus communis agglutinin I), N-acetylglucosamine (Griffonia simplicifolia agglutinin II) as well as &alpha1,6-linked (Aleuria aurantia lectin), &alpha 1,3-linked (Lotus tetragonolobus agglutinin), and &alpha 1,2-linked (Ulex europaeus agglutinin) fucose

• Results indicate differences between early and advanced RA stages in the terminal sugar exposition of synovial IgG and IgA, but not IgM
• Galactose-deficient glycotope with exposed N-acetylglucosamine of the synovial 33.1-kDa IgG fragment appeared exclusively in early stage of RA
• Glycotope of intact synovial IgG and IgA present in both groups, although higher proportions in advanced RA
• Proportions of sialyl and fucosyl determinants of intact synovial A and G immunoglobulins clearly lower in early RA group than in advanced

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