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See Latest ArticlesThe ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
Arthritis Research & Therapy, 10/13/09
Hollis-Moffatt JE et al – Angiogenesis is an important process in the development of destructive synovial pannus in rheumatoid arthritis (RA). The ITGAV gene encodes a cell-cycle-associated antigen, integrin alpha (v) beta (3), which plays a role in RA angiogenesis. Previously, two independent studies identified an association between the major allele of the ITGAV single nucleotide polymorphism (SNP), rs3738919, and RA. Association of ITGAV SNP rs7378919 with RA was not replicated in NZ or Oxford (UK) case-control sample sets. Meta-analysis of these and previously published data lends limited support for a role for the ITGAV in RA in Caucasians of European ancestry.
Methods- Compared genotype frequencies in 740 NZ Caucasian RA patients and 553 controls genotyped for rs3738919, using a polymerase chain reaction-restriction fragment length polymorphism assay
- A TaqMan genotyping SNP assay used to type 713 Caucasian RA patients and 515 control samples from Oxford (UK) for rs3738919 variant
- Association of rs3738919 with RA tested in these 2 samples using the Chi-square goodness-of-fit test
- Mantel-Haenszel test used to perform a meta-analysis, combining genetic results from 4 independent Caucasian case-control cohorts, comprising 3527 cases and 4126 controls
- Haplotype analysis also performed using SNPs rs3911238, rs10174098 and rs3738919 in Wellcome Trust Case Control Consortium, NZ and Oxford case-control
- No evidence for association between ITGAV and RA in either NZ or Oxford samples sets (OR = 0.88, Pallelic = 0.11 and OR = 1.18, Pallelic = 0.07, respectively)
- Inclusion of data in a meta-analysis (random effects) of 4 independent cohorts (3527 cases and 4126 controls) weakens support for the hypothesis that rs3738919 plays a role in the development of RA
- No consistent haplotype associations evident
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