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See Latest ArticlesFactors associated with osteonecrosis in Thai lupus patients: A case control study
Journal of Clinical Rheumatology (JCR), 10/07/09
Uea-areewongsa P et al. – The presence of renal involvement was associated with ON and the antimalarial use may have a protective effect for ON in Thai patients with SLE. The findings from this study further support the use of antimalarial drugs in SLE patients.
Methods- Retrospective nested case-control study from SLE patients
- Had clinically apparent ON (confirmed by plain radiographs or magnetic resonance imaging)
- For each case, control was selected and matched to case by age and disease duration
- Main outcome measure odds ratio (OR) of ON among SLE patients
- Clinical and laboratory variables thought to be risk factors of ON variables were compared between patients who did and did not develop ON
- Significant and clinically relevant variables examined by stepwise logistic regression model
- Of 186 SLE patients, 41 patients identified who developed ON during the course of follow-up
- 20patients available for data analysis
- From the univariate analysis, incidence of renal involvement and use of steroids (recorded as evidenced by maximum and mean daily prednisolone dose) significantly higher in ON group than controls
- Use of antimalarials significantly lower in patients with ON than in controls
- No difference in disease activity, lipid profiles or anticardiolipin antibody found between groups
- In logistic regression, presence of renal involvement remained as positive associated factor for ON (OR = 7.80, CI = 1.249-48.748) and the use of antimalarial drugs was a negative associated factor for ON (OR = 0.09, CI = 0.009-0.961)
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Fyn and CD70 Expression in CD4+ T Cells from Patients with Systemic Lupus Erythematosus
Journal of Rheumatology, 12/08/09
Sleep disturbance in lupus patients
International Journal of Clinical Rheumatology, 12/07/09
Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population
Lupus, 12/07/09
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