Rheumatology

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Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica
Annals of Rheumatic Diseases, 10/09/09

Jiménez-Palop M et al. – US may be a responsive additional tool in monitoring CST response in PMR patients in daily practice and multicentre trials.

• 53 patients with active PMR who started treatment with prednisone from 6 Spanish centres prospectively studied
• Clinical, laboratory, and US assessment at baseline, 4 weeks, and 12 weeks
• US investigation consisted of detection and quantification of inflammatory findings in shoulder and hip
• Responsiveness of clinical, laboratory and US parameters tested by SRM
• Intraobserver and interobserver reliability between US investigators were assessed

• At baseline, 34 (69%) patients presented inflammation in at least bilateral site
• During follow-up, clinical, laboratory, and US variables showed parallel decrease
• Significant decrease in US inflammatory parameters found at week 4
• After 4 weeks and 12 weeks of CST therapy, US inflammatory findings showed similar or better sensitivity to change than clinical and laboratory markers of PMR activity
• Intraobserver and interobserver intraclass correlation coefficients 0.96 and 0.99

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