Rheumatology

Your Article Summary

See Latest Articles

Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis
Annals of Rheumatic Diseases, 10/09/09

Gourh P et al. – Polymorphisms in the TNFSF4 gene region are associated with susceptibility to SSc and its clinical and autoantibody subsets. TNFSF4 may be another gene that confers risk to multiple autoimmune diseases.

• Collection of 1059 SSc cases and 698 controls
• Tested 9 single nucleotide polymorphisms (SNPs) in TNFSF4 gene region, previously associated with susceptibility to SLE, for association with SSc

• Case-control comparisons revealed significant association between susceptibility to SSc and the minor alleles at SNPs rs1234314 , rs2205960 , and rs844648
• Minor allele at rs844644 protective
• Analysis of subsets of SSc patients demonstrated significant associations of TNFSF4 SNPs with both limited and diffuse SSc as well as specific SNPs that were associated with SSc-associated autoantibodies
• Analyses suggest potential interaction between two TNFSF4 SNPs, rs2205960 and rs844648, with regards to SSc susceptibility

Today in Connective Tissue Dz...keeping you current

Receive free subspecialty "5-minute updates" via email

Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
Journal of Rheumatology, 11/20/09

The clinical course of polymyalgia rheumatica in Chinese
Clinical Rheumatology, 11/19/09

Evaluation of anti-ribosomal P protein immunoassay in Japanese patients with connective tissue diseases: comparison with an indirect immunofluorescence assay
Scandinavian Journal of Rheumatology , 11/19/09

 See all of Connective Tissue Dz