Rheumatology

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Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus
Atherosclerosis, 10/07/09

de Leeuw K et al. – The age-related increase in IMT is higher in SLE, indicating that atherosclerosis is accelerated in SLE patients. This is mainly due to disease-related risk factors, as disease duration was independently associated with IMT.

• 74 SLE patients, age ranging from 13 to 69 years, and 74 age- and sex-matched controls included
• IMT of common carotid artery determined by B-mode ultrasound imaging
• Traditional risk factors for atherosclerosis and disease-related factors recorded
• Cardiovascular risk estimated using systematic coronary risk evaluation (SCORE)
• Markers of inflammation (C-reactive protein, CRP) and endothelial activation (thrombomodulin, vascular cell adhesion molecule-1, and von Willebrand factor) determined
• Measurements repeated in 52 patients after a follow-up of 32 ± 7 mos

• IMT increased in SLE patients compared to controls
• Prevalence of smoking and hypertension, use of lipid-lowering drugs and SCORE higher in patients, as well as levels of CRP and markers of endothelial activation
• Age-related increase in IMT significantly higher in patients than controls
• In multivariate analysis, age and disease duration independently related to IMT
• Increase in IMT during follow-up related to age only

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