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Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
Arthritis Research & Therapy, 10/06/09

Corcione A et al. – This study demonstrates for the first time an expansion of activated switch memory B cells and of IgG-secreting plasma blasts in the SF from oligoarticular JIA patients. Memory B cells belonged to either the CD27+ or the CD27- subsets and expressed CD86, suggesting their involvement in antigen presentation to T cells. Patterns of chemokine receptor expression on CD27+ and CD27- switch memory B cells delineated potential mechanisms for their recruitment to the inflamed joints.

Methods

B cells from synovial fluid (SF) and peripheral blood (PB) of 25 JIA patients, as well as from PB of 20 controls of comparable age, characterized by multi color flow cytometry
Immunoglobulin-secreting cells were detected by ELISPOT
Immunohistochemical analyses of synovial tissue from 3 JIA patients performed

Results

JIA SF B cells enriched in CD27+ and CD27- switch memory B cells, but not in CD27+ IgM memory B cells, compared to patient and control PB
Plasma blasts more abundant in SF and secreted higher amounts of IgG.
Lymphoid aggregates not organized in follicle-like structure detected in synovial tissue sections and surrounded by CD138+ plasma cells
Transitional B cells significantly increased in JIA PB vs SF or control PB
CCR5, CCR8, CXCR2, and CXCR3 were up-regulated, whereas CCR6, CCR7, and CXCR5 were down-regulated on SF CD27+ and CD27- switch memory B cells compared with circulating counterparts
SF CD27+ and CD27- switch memory B cells expressed at high levels costimulatory molecule CD86 and activation marker CD69

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