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Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
Arthritis Research & Therapy, 10/06/09

Gourh P et al. – Plasma cytokine profiles differ in SSc patients based on the presence of SSc-associated autoantibodies. Plasma cytokine profiles in SSc patients may also be affected by disease duration and the pattern of internal organ involvement.

Methods

Plasma from 444 SSc patients and 216 healthy controls
Patients classified according to presence of ACA, ATA, ARA, or none of the above
Levels of 13 cytokines determined using multiplex assays

Results

Compared to females, healthy control males had higher plasma levels of interleukin (IL)-2 , IL-5 and IL-8
In controls, IL-6 and IL-17 levels increased with advancing age.
After adjusting for age and gender, SSc patients had higher circulating levels of tumor necrosis factor-alpha (TNF-alpha) , IL-6 , and interferon-gamma (IFN-g) and lower IL-17 and IL-23
Disease duration influenced cytokine profiles
IL-6 elevated in ATA+ and ARA+ patients, but not in ACA+ patients.
IL-8 uniquely increased in ATA+ subset while both ATA+ and ACA+ subsets had elevated IFN-g and IL-10
IL-5 only significantly increased in ACA+ subset
Patients with interstitial lung disease had elevated IL-6 and patients with pulmonary hypertension had elevated IL-6 and IL-13

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