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Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus
Modern Rheumatology, 10/22/09
Kamiya K et al. – The authors report the case of a patient with systemic lupus erythematosus (SLE) who first revealed hemophagocytic syndrome (HPS), which was treated successfully with glucocorticoid and intravenous cyclophosphamide. This case showed that TTP with normal ADAMTS–13 activity is B–cell dependent and indicated that B–cell depletion might exacerbate some autoimmune conditions in SLE.
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