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Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
Modern Rheumatology, 10/05/09

Higashiyama R et al. – Elevated HDAC7 expression in human OA may contribute to cartilage degradation via promoting MMP-13 gene expression, suggesting the critical role of MMP-13 in OA pathogenesis.

Methods

Correlation between HDACs and MMP-13 investigated
Expression of different HDACs in cartilage from OA patients and healthy donors compared

Results

HDAC7 showed significant elevation in cartilage from OA patients
High level of HDAC7 expression in OA cartilage also confirmed by immunohistochemistry
Knockdown of HDAC7 by small interference RNA (siRNA) in SW1353 human chondrosarcoma cells strongly suppressed interleukin (IL)-1-dependent and independent induction of MMP-13 gene expression

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