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See Latest ArticlesExpression and function of the C-class chemokine lymphotactin (XCL1) in Wegener's granulomatosis
Journal of Rheumatology, 10/05/09
Blaschke S et al. – Our data indicated increased expression of XCL1 in CD4+ and CD8+ T cells in WG. Considering its function as a lymphocyte-specific chemoattractant, XCL1 might be a key modulator of T cell recruitment in WG. Functional studies further suggest that XCL1 may support vascular inflammation by induction of release of interleukin 8 in PMN.
Methods- Sera and peripheral blood mononuclear cells (PBMC) obtained from 16 patients with WG and healthy controls
- Serum XCL1 concentrations measured by ELISA
- PBMC subjected to flow cytometry for activation markers and immunophenotype of XCL1+ T cells
- Renal biopsies analyzed by double-label immunohistochemistry
- In vitro stimulation of PMN with XCL1 performed to study its function
- Flow cytometry demonstrated coexpression of activation markers CD25, CD69, and HLA-DR in significantly higher proportion of T cells in WG patients in comparison to controls
- XCL1 found to be mainly expressed in CD4+CD28– T cells in WG patients
- Presence of XCL1 was only detected within interstitial CD4+ and CD8+ T cells in renal biopsies
- Functional studies demonstrated significant enhancement of IL-8 production in isolated PMN after in vitro stimulation with XCL1
- No significant differences in XCL1 serum concentrations between WG patients and controls
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