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See Latest ArticlesReactivation of hepatitis B viral infection in inactive HBSAg carriers following anti-tumor necrosis factor-alpha therapy
Journal of Rheumatology, 10/05/09
Chung SJ et al. – 1 HBV reactivation case among 8 inactive HBsAg carriers following anti-TNF-alpha therapy. This finding supports the prophylactic use of antiviral agents in HBV carriers, even if they have normal liver function or an undetectable viral load.
Methods- The medical records of 103 patients [59 with AS, 41 with RA, 2 with juvenile RA, and 1 with psoriatic arthritis] had been treated with anti-TNF-&alpha therapy were reviewed retrospectively.
- Data on seropositivity of HBV, HBV load, and serum aminotransferases prior to and after initiation of anti-TNF-alpha therapy obtained
- 8 patients inactive HBsAg carriers, and all of them had normal liver function and undetectable HBV load prior to anti-TNF-alpha therapy
- Reactivation of hepatitis B occurred in 1 patient during course of anti-TNF-&alpha therapy
- After third infusion of infliximab 5 mg/kg at Week 6, a blood test showed that patient had normal liver function
- When patient returned for fourth infusion of infliximab at Week 14, a blood test showed markedly elevated AST/ALT levels and increased viral DNA by HBV PCR
- Fourth infliximab infusion was canceled, and entecavir 0.5 mg/day was prescribed
- AST/ALT levels began to decrease and returned to normal range after 3 mos
- Followup HBV PCR showed negative results
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Fetuin-A and interleukin-18 levels in ankylosing spondylitis
International Journal of Rheumatic Diseases, 12/15/09
Matrix metalloproteinase-28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs
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Quantitative Recording of Physician Clinical Estimates, Beyond a Global Estimate and Formal Joint Count, in Usual Care: Applying the Scientific Method, Using a Simple One-Page Worksheet
Rheumatic Disease Clinics of North America, 12/14/09
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