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See Latest ArticlesMonocyte derived interleukin (IL)-23 is an important determinant of synovial Il-17A expression in rheumatoid arthritis
Journal of Rheumatology, 10/05/09
Stamp LK et al. – IL-17A gene expression occurs in only a subset of rheumatoid synovial membranes. IL-23 gene expression is higher in IL-17A+ versus IL-17A– membranes. In keeping with this, IL-17A+ and IL-23+ cells colocalize in synovial membranes. IL-17 is not an absolute requirement in RA but may be important in amplifying the inflammatory response. Anti-IL23 therapies may have a role in those patients with IL-17A expression.
Methods- Total RNA isolated from 25 synovial membranes obtained from 20 patients with RA
- Quantitative real-time polymerase chain reaction used to measure IL-17A, IL-12p35, IL-23p19, p40, and GAPDH expression
- Immunohistochemistry utilized to determine cell type and proximity of IL-17A, IL-12, and IL-23 in rheumatoid synovium
- IL-17A present in 13/25 synovia
- IL-12p35 present in all samples while IL-23p19 present in 23/25
- p40 was present in 23/25 samples
- 2 p40– samples both were IL-23p19 and IL-12p35 positive
- Mean expression of IL-23p19 was significantly higher in the IL-17A+ versus IL-17A– synovia
- All IL-17A+ cells in vicinity of IL-23+ cells
- IL-12+ cells were both close to and removed from IL-17A+ cells
- Only a proportion of CD3+T cells appeared to produce IL-17A
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Today in Rheumatoid Arthritis...keeping you current
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Arthritis Care and Research , 11/03/09
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