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The Efficacy and Duration of Intra-articular Corticosteroid Injection for Knee Osteoarthritis: A Systematic Review of Level I Studies
Journal of the American Academy of Orthopedic Surgeons, 10/01/09
Hepper CT et al. – Following an electronic search of multiple databases and a review of reference lists from various articles, the authors found 6 trials in 5 papers that compared corticosteroid versus placebo and four papers that compared different corticosteroids. Results of corticosteroid compared with placebo showed both a statistically and clinically significant reduction in pain at 1 week, with an average difference between groups of 22%. 2 of 4 trials showed triamcinolone to be more effective in pain reduction than other corticosteroids. The authors concluded that intra–articular corticosteroids reduce knee pain for at least 1 week and that intra–articular corticosteroid injection is a short–term treatment of a chronic problem.
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Safety of TNF blocking agents in rheumatic patients with serology suggesting past-hepatitis B state: Results from a cohort of 21 patients
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Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis
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