Rheumatology Medical News about Amyloidosis Familial Mediterranean Fever Colchicine

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Prevention of Amyloidosis in Familial Mediterranean Fever with Colchicine: A Case-Control Study in Armenia
Medical Principles and Practice, 10/05/09

Sevoyan MK et al. – The study demonstrated that colchicine treatment is effective in preventing amyloidosis among Armenian patients with FMF and that earlier initiation and continuous therapy at an adequate dose of 1.2–1.8 mg/day may be associated with a decreased amyloidosis risk among Armenian patients with FMF.

Methods

The study included 99 Armenian patients from the Center of Medical Genetics database with genetically ascertained FMF; 33 had renal amyloidosis and 66 were randomly selected control patients without renal amyloidosis.
Self–reported colchicine use was assessed by interviewer–based questionnaire.

Results

The patients with incident amyloidosis were more likely to be older men, but younger at the time of disease onset, and more likely to have had a family history of amyloidosis and M694F mutation in the MEFV gene compared to patients without amyloidosis.
The risk of amyloidosis decreased with adequate colchicine use rather than nonadequate use, continuous colchicine use rather than interrupted use, earlier rather than later initiation age of colchicine treatment, current colchicine rather than ever/never colchicine use.

<< Previous
C1q inhibits immune complex-induced interferon-[alpha] production...

Next >>
Lymphocytic enterocolitis in systemic lupus erythematosus

Heart rate variability in familial Mediterranean fever
Rheumatology International, 11/06/09 Relevance Score: 92%

MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09 Relevance Score: 89%

Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcets disease
Clinical Rheumatology, 10/06/09 Relevance Score: 87%

Neutrophil-derived S100A12 as novel biomarker of inflammation in Familial Mediterranean Fever
Annals of Rheumatic Diseases, 10/01/09 Relevance Score: 87%

Familial Mediterranean fever gene mutations in the inner northern region of Turkey and genotype-phenotype correlation in children
Journal of Paediatrics and Child Health, 10/27/09 Relevance Score: 79%