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See Latest ArticlesSystemic lupus erythematosus and the risk of cardiovascular disease: Results from the Nurses Health Study
Arthritis Care and Research , 10/01/09
Hak AE et al. – In this prospective population-based study, results show a statistically significant >2-fold increased risk of cardiovascular disease among participants with SLE. The risk was not as high as has been previously reported, which may have been due to the relatively high age at diagnosis of SLE in this cohort.
Methods- Prospective cohort study among 119,332 women participating in the Nurses' Health Study
- Participants free of cardiovascular disease and SLE at baseline in 1976
- Incident SLE confirmed by medical record review
- Cardiovascular events included fatal and nonfatal MI, stroke, CABG, and angioplasty
- RR of cardiovascular events among participants with SLE as compared with those without SLE was estimated using Cox proportional hazards models
- Over 28 years of followup (2.9 million person-years)
- 8,169 cardiovascular events occurred
- 148 women developed incident SLE
- Mean age at SLE diagnosis was 52.6 years
- 20 participants with SLE developed subsequent cardiovascular event
- After adjusting for potential confounding factors, including age, race, cardiovascular risk factors, and medication use, the RR of a cardiovascular event in women with SLE compared with those without SLE was 2.26
- When end points were analyzed separately, RR for coronary heart disease was 2.25 (95% CI 1.37-3.69) and the RR for stroke was 2.29 (95% CI 0.85-6.15)
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