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25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus
Arthritis Care and Research , 10/01/09

Wu PW et al. – This study demonstrates that vitamin D levels are low in women with SLE and significant associations exist with selected cardiovascular risk factors, although most of these associations can be explained by BMI.

Methods

181 women with SLE included demographics
Included demographics: SLE activity and damage assessments, cardiovascular risk factors, medications, and laboratory assessments of inflammatory markers and 25(OH)D levels
Multiple linear and logistic regressions used to estimate the association of 25(OH)D levels with cardiovascular risk factors

Results

Mean age and disease duration were 43.2 and 11.9 years
Mean 25(OH)D level was 27.1 ng/ml and 62.2% had 25(OH)D levels <30 ng/ml
Lower 25(OH)D levels significantly associated with higher diastolic BP, LDL cholesterol, lipoprotein(a), BMI, and fibrinogen levels, as well as self-reported hypertension and DM
Lower 25(OH)D levels also significantly associated with higher SLE disease activity and damage scores
After adjustment for age, seasonal variation, and race/ethnicity, lower 25(OH)D levels also significantly related to higher fasting serum glucose
With further adjustment for BMI, associations between 25(OH)D and cardiovascular risk factors no longer significant

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