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Knee osteoarthritis in obese women with cardiometabolic clustering
Arthritis Care and Research , 09/30/09

Sowers M et al. – Knee OA was twice as frequent in obese women with cardiometabolic clustering compared with those without, even when considering age and joint asymmetry. Obesity/cardiometabolic clustering was also associated with persistent knee pain and impaired physical functioning.

• Knee OA was defined as a Kellgren/Lawrence score 2 on weight-bearing radiographs
• The difference between lateral and medial knee JSW was used to determine joint space asymmetry

• In a sample of women (n = 482, mean age 47 years), prevalences of knee OA and persistent knee pain were 11% and 30%, respectively
• The knee OA prevalence in nonobese women without cardiometabolic clustering was 4.7%, compared with 12.8% in obese women without cardiometabolic clustering and 23.2% in obese women with cardiometabolic clustering
• Nonobese women without cardiometabolic clustering were less likely to perceive themselves as limited compared with women in all other obesity/cardiometabolic groups
• Similar associations were seen with knee pain and physical functioning measures
• The inclusion of a joint space asymmetry measure was associated with knee OA but not with knee pain or physical functioning

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