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Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritis
Arthritis & Rheumatism, 10/01/09

Charles-Schoeman C et al. – Proinflammatory HDL in this RA patient cohort was associated with active disease and an altered protein cargo as compared with antiinflammatory HDL in RA patients and in healthy controls. The antiinflammatory function of HDL was inversely correlated with systemic inflammation in RA patients.

Methods

132 RA patients
Antiinflammatory function of HDL was assessed by a cell-free assay
Proinflammatory HDL was defined by an HDL inflammatory index ≥ 1
Plasma and HDL-associated protein levels of apolipoprotein A-I (Apo A-I), haptoglobin, hemopexin, hemoglobin, and myeloperoxidase (MPO) were measured by direct and sandwich enzyme-linked immunosorbent assays
Lecithin:cholesterol acyltransferase (LCAT) activity measured by commercially available assay

Results

Age, disease activity, the presence of erosive disease, non-Caucasian race, and smoking significantly associated with proinflammatory HDL on multivariate analysis
Patients with proinflammatory HDL had higher measures of systemic inflammation
Significant correlation observed between RA disease activity (using the Disease Activity Score in 28 joints) and the HDL inflammatory index
Compared with patients with antiinflammatory HDL, patients with proinflammatory HDL had significantly higher levels of haptoglobin, hemoglobin, Apo A-I, and MPO associated with HDL
LCAT activity lowest in patients with proinflammatory HDL, but significantly reduced in RA patients with antiinflammatory HDL as compared with healthy controls

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