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Association of tumor necrosis factor alpha and IL-10 promoter polymorphisms with rheumatoid arthritis in North Indian population
Rheumatology International, 10/02/09
Gambhir D et al. – Allele A at TNFalpha ?308 locus provides protection against RA in North Indian population while another TNF allele A at ?863 position had weak association with earlier onset of disease in female patients. On the other hand promoter polymorphisms of IL–10 did not affect susceptibility but polymorphism at ?819/?592A was associated with higher disease activity scores at baseline.
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MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
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