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See Latest ArticlesExpression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis
Scandinavian Journal of Rheumatology , 10/01/09
Jiao Z et al. – The present study demonstrated that T helper cells from RA patients display a significantly altered expression profile of Notch receptors and enhanced activation of Notch signalling compared with HC.
Methods- Expression of Notch receptors in peripheral lymphocytes of RA patients assessed by both flow cytometry and real-time polymerase chain reaction
- Expression of representative Notch target gene HES-1 and regulatory gene NUMB in purified T helper cells from RA patients determined by real-time PCR,
- Expression of Notch intracellular domain determined by immunoblot analysis
- Increased expression of Notch 2, Notch 3, and Notch 4 in T helper cells from active RA patients, among which increased expression of Notch 3 was mainly by activated T cells
- Expression of Notch 3 in T cells decreased in inactive RA patients and the level was similar to that of healthy controls (HC)
- Notch receptors were rarely observed on B cells and no difference in expression was found between RA patients and HC
- T helper cells from RA patients exhibited increased expression of target gene HES-1 but decreased expression of negative modulation gene NUMB of Notch signalling
- Increased nuclear translocation of Notch-ICD in T helper cells from active RA disease
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