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The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
Rheumatology, 09/24/09

Kwanet BCH al. – The urinary expression of TH17-related genes is increased in SLE . The degree of up-regulation is inversely related to systemic and renal lupus activity, as well as urinary expression of TH1-related genes. Urinary expression of TH17-related genes increased again after successful immunosuppressive treatment of active disease. Our findings suggest a regulatory role of TH17-related cytokines in pathogenesis of lupus nephritis.

Methods

Quantification ofmRNA expression of IL-17, -23, -27 and retinoic-acid-related orphan receptor (ROR)-, the regulator for the development and function of TH17, in the urinary sediment of 23 subjects with active lupus nephritis
25 subjects with history of lupus nephritis in remission
30 SLE patients with no history of renal involvement
8 healthy subjects

Results

All 3 groups of lupus patients had a higher urinary expression of TH17-related cytokines than controls
Urinary expression of IL-17 and -27 found to be inversely correlated with the SLEDAI score
For patients with active lupus nephritis, the histological activity index of kidney biopsy found to be inversely correlated with the urinary expression of ROR- , IL-17 and IL-23
Urinary expression of IL-17, -23, -27 and ROR was found to be inversely correlated with the urinary expression of IFN- and T-bet, the key transcription factor of type 1 Th cells
After 6 months of treatment, urinary IL-27 expression rose significantly in patients with complete response but remained unchanged in those with partial or no response

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