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Evaluation of anti-ribosomal P protein immunoassay in Japanese patients with connective tissue diseases: comparison with an indirect immunofluorescence assay
Scandinavian Journal of Rheumatology , 09/24/09

Muro Y et al. – Routine screening for anti-P antibodies by IIF has low sensitivity. ELISAs using cut-off values established by individual facilities are suitable for detecting anti-P antibodies and provide a tool with good diagnostic characteristics, on a parity with Western Blotting (WB)

Methods

Anti-P antibodies were measured by two different commercially available ELISA kits
WB in 239 outpatients
99 with systemic sclerosis (SSc)
73 with SLE, 45 with dermatomyositis
22 with Sjgren's syndrome
Sera positive for anti-P antibodies by WB were analysed by IIF

Results

Frequency of positive WB findings in SLE (18/73, 25%) was higher than other diseases
ELISA kits A and B for anti-P antibodies showed 21% and 43% sensitivity, and 93% and 88% specificity, respectively, for diagnosing SLE
Receiver operating characteristic (ROC) curve analysis determined a new cut-off threshold but revealed that both ELISA kits still had good diagnostic characteristics

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