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See Latest ArticlesEffect of etanercept on serum levels of soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) and vascular endothelial growth factor in patients with rheumatoid arthritis
Scandinavian Journal of Rheumatology , 09/24/09
Klimiuk PA et al. –Besides a rapid suppression of disease activity, serum sCAM and VEGF concentrations are downregulated following anti-tumour necrosis factor alpha (TNF) therapy combined with MTX. Prolonged treatment with etanercept sustained or even more remarkably diminished the sCAM and VEGF serum concentrations.
Methods- Patients were receiving 50 mg/week of subcutaneous etanercept and 10-25 mg/week of methotrexate (MTX)
- Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin)measured by enzyme-linked immunosorbent assay (ELISA) in 18 RA patients (prior to injection) at 0, 3, 6, 9, and 12 months
- Decrease in serum levels of sICAM-1 , sVCAM-1 , sE-selectin , and VEGF observed in RA patients after 3 months treatment with etanercept
- 6 months of therapy with etanercept prolonged suppression of serum sICAM-1;diminished sVCAM-1, sE-selectin, and VEGF concentrations as compared to baseline
- Treatment effectively diminished sICAM-1, sVCAM-1, and VEGF levels at months 9 and 12 , and less significantly sE-selectin
- The Disease Activity Score including a 28-joint count (DAS28) measured at 3, 6, 9, and 12 months decreased significantly compared to baseline
Today in Basic Science/Genetics...keeping you current
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Urinary cadmium, osteopenia, and osteoporosis in the US population
Osteoporosis International, 11/27/09
Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)
Central European Journal of Medicine, 11/25/09
Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid
Osteoporosis International, 11/25/09
Today in Clinical Pharmacology...keeping you current
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Safety of TNF blocking agents in rheumatic patients with serology suggesting past-hepatitis B state: Results from a cohort of 21 patients
Arthritis Research & Therapy, 11/27/09
Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09
Today in Rheumatoid Arthritis...keeping you current
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Safety of TNF blocking agents in rheumatic patients with serology suggesting past-hepatitis B state: Results from a cohort of 21 patients
Arthritis Research & Therapy, 11/27/09
CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
Arthritis Research & Therapy, 11/25/09
Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis
Annals of Rheumatic Diseases, 11/24/09
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