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In situ deformation of cartilage in cyclically loaded tibiofemoral joints by displacement-encoded MRI
Osteoarthritis and Cartilage , 09/23/09

Chan DD et al. – This study determined the depth-dependent displacements and strains in intact juvenile porcine tibiofemoral joints using displacement-encoded imaging. Displacement and strain distributions reflect the heterogeneous biochemistry of cartilage and the biomechanical response of the tissue to compression in the loading environment of an intact joint. This unique information about the biomechanics of cartilage has potential for comparisons of healthy and degenerated tissue and in the design of engineered replacement tissues.

Methods

Juvenile porcine tibiofemoral joints cyclically compressed at 1 and 2 times body weight at 0.1 Hz to achieve a quasi-steady state load–displacement response
7.0 T MRI scanner used for displacement-encoded imaging with stimulated echoes and a fast spin echo acquisition (DENSE-FSE) in 8 intact joints
Two-dimensional displacements and strains determined throughout the thickness of the tibial and femoral cartilage then normalized over the tissue thickness

Results

Two-dimensional displacements and strains heterogeneous through the depth of femoral and tibial cartilage under cyclic compression
Strains in the loading direction compressive and maximal in middle zone of femoral and tibial cartilage
Tensile strains observed in direction transverse to loading

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