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Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis
Osteoarthritis and Cartilage , 09/23/09

Richardot P et al. – Nitration of tyrosine residues of type III collagen N-telopeptide is increased in the synovial tissue of patients with knee OA. Measurements of serum IIINys level may be useful for the clinical investigation of oxidative-related alterations of synovial tissue metabolism in OA.

Methods

Polyclonal antibody directed against the nitrated QY*DSY*DVKSG sequence from type III collagen N-telopeptide generated
Synovial tissues from patients with knee OA (n = 4) and RA (n = 4) were analyzed by immunohistochemistry for IIINys
Serum IIINys levels were measured by enzyme-linked immunosorbent assay in 87 patients with painful knee OA (mean age: 63.0 ± 8.0 years, Kellgren–Lawrence score II–III)
Same observed in 40 sex and age-matched healthy controls

Results

Antibody highly specific for the nitrated IIINys sequence
High IIINys immunoreactivity detected in the synovial tissues from all patients with OA and RA with a preferential localization in the intimal layer
Serum IIINys levels on average 1.5-fold higher in knee OA than in healthy controls
Significantly correlated with C-reactive protein values

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