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Quantitative analysis of subchondral sclerosis of the tibia by bone texture parameters in knee radiographs: site-specific relationships with joint space width
Osteoarthritis and Cartilage , 09/24/09

Wong AKO et al. – High reproducibility in quantifying bone sclerosis using Tb.Sp and its significant relationship with JSW demonstrated potential for assessing OA progression. Increased trabecular FE and reduced porosity observed with smaller JSW suggest collapsing subchondral bone or trabecular plate perforation in advanced knee OA.

Methods

Digitized fixed-flexion knee radiographs analyzed for run-length and topological BTX parameters in subchondral region using algorithm.
Medial JSW(x) was computed at x = 0.200, 0.225, 0.250 and 0.275 according to a coordinate system defined by anatomic landmarks
mJSW determined for medial and lateral compartment lesions
KA angles determined from radiographs using anatomic landmark-guided algorithm
JSW measures and magnitude of knee malalignment were correlated with BTX parameters
Reproducibility of BTX parameters measured by root-mean square coefficients of variation

Results

Run-length BTX parameters were highly reproducible
Topological parameters showed poorer reproducibility
TKA participants (17 women, 13 men; age: 66 ± 9 years
BMI: 31 ± 6 kg m?2
Reduced trabecular spacing and increased free ends were correlated with decreased JSW after accounting for BMI, gender and knee malalignment

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