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T2 assessment and clinical outcome following autologous matrix-assisted chondrocyte and osteochondral autograft transplantation
Osteoarthritis and Cartilage , 09/25/09
Salzmann GM et al. – These findings indicate that MACT and OCT result in a different ultrastructural outcome, which is only partially represented by the clinical picture.
Methods- Eighteen patients that underwent MACT or OCT for treatment of cartilage defects at the knee joint (nine MACT, nine OCT)
- Matched for gender (one female, eight male pairs)
- Matched for age (33.8)
- Matched for BMI (28.3)
- Matched for defect localization, and postoperative interval (41.6 months)
- T2 assessment was by T2 maps, while the clinical evaluation included the Lysholm and Cincinnati knee scores, a visual analogue scale (VAS) for pain, the Tegner activity scale, and the Short Form-36
- Global T2 values of healthy femoral cartilage (HC) were similar among groups
- T2 values of the RT following MACT (46.8 ms, SD 8.6) were significantly lower when compared to RT T2 values after OCT (55.5 ms, SD 6.7)
- MACT values were also significantly lower in comparison to HC (52.5 ms, SD 7.9) within MACT patients , while OCT values were significantly higher compared to HC (49.9 ms, SD 5.1) within OCT patients
- Clinical outcome following MACT consistently superior to that after OCT
- Only Lysholm score reached the level of significance
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