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Osteoporosis and related risk factors in renal transplant recipients
Transplantation Proceedings, 09/25/09

Ahmadpoor P et al. –Decreased bone mineral density is a common problem after kidney transplantation. Osteoporosis has a major role in morbidity in these patients. Osteoporosis is a frequent complication that requires detection and treatment to reduce morbidity.

• Evaluated the incidence of osteoporosis and determined risk factors in 77 patients
• Patients aged 17 to 50 years
• Renal transplantation 6 months to 2 years previously
• Bone mineral densitometry performed using dual-energy x-ray absorptiometry

• Incidence of osteoporosis 26% (20 of 77 patients)
• Mean age of affected patients was 34.6 (8.7) years
• Most common sites of osteoporosis were the hip (osteoporotic in 19 patients [24.7%] and osteopenic in 42 [54.5%]) and the spine (osteoporotic in 6 patients [7.8%] and osteopenic in 52 [67.5%])
• Significant relationship between posttransplantation creatinine concentration and hip osteoporosis
• No relationship observed between osteoporosis and age, sex, body mass index, duration of hemodialysis therapy, cumulative dosage of any drugs, or use of pulsed methylprednisolone therapy
• Hip or spine z score of 1 or less had no relationship to number of steroid pulse sessions but was significantly related to the total dosage of cyclosporine , prednisolone , and mycophenolate mofetil
• Hip z score of less than 1 related to the posttransplantation period

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