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Elevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patients
Osteoarthritis and Cartilage , 09/18/09

Gao SG et al. – Osteopontin in synovial fluid and articular cartilage is associated with progressive joint damage and is likely to be a useful biomarker for determining disease severity and progression in knee osteoarthritis.

Methods

Fifty patients aged 48–81 years with knee osteoarthritis and 10 healthy controls were enrolled in this study
Anteroposterior knee radiographs or/and Mankin score were taken to determine the disease severity of the affected knee
The radiographic grading of osteoarthritis in the knee was performed by using the Kellgren-Lawrence criteria
Osteopontin levels in synovial fluid were measured using enzyme-linked immunosorbent assay
Osteopontin levels in articular cartilage were assessed by immunohistochemical methods

Results

Compared to healthy controls, osteoarthritis patients had higher osteopontin concentration in synovial fluid (4519.60 ± 1830.37, 95%CI 3999.42-5039.79 vs 1179.70 ± 303.39, 95%CI 1035.53-1438.74 pg/ml, p < 0.001)and articular cartilage(0.6 ± 0.06, 95%CI 0.59-0.62 vs 0.43 ± 0.07, 95%CI 0.38-0.48, p < 0.01). In addition, synovial fluid osteopontin levels showed a positive correlation with articular cartilage osteopontin levels (r = 0.411, 95%CI 0.150-0.619, p = 0.003)
Subsequent analysis showed that synovial fluid osteopontin levels significantly correlated with severity of disease (Spearman's ? = 0.581, 95%CI 0.335-0.726, P < 0.001)
Furthermore, the articular cartilage levels of osteopontin also correlated with disease severity (Spearman's ? = 0.675, 95%CI 0.500-0.808, p < 0.001)

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