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Signal Transduction and Metabolism in Chondrocytes is Modulated by Lactoferrin
Osteoarthritis and Cartilage , 09/21/09
Brandl N et al. – Lactoferrin is a robust regulator of chondrocyte metabolism, comparable to TGFß1. The catabolic influence together with the proliferative stimulus indicates a function as an early phase cytokine, enhancing MMPs, necessary for degradation of damaged tissue and stimulating proliferation of chondrocytes, necessary for reconstruction.
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