Rheumatology Medical News about muscle damage

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Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis
Current Opinion in Rheumatology, 09/30/09

Henriques–Pons A et al. – Current data indicate that the ER stress, nuclear factor–[kappa]B pathway and autophagy are active in the skeletal muscle of myositis patients, and the proinflammatory nuclear factor–[kappa]B pathway connects the immune and nonimmune pathways of muscle damage. The relative contributions of each of these pathways to muscle fiber damage are currently unclear. Therefore, further defining the role of these pathways in disease pathogenesis should help to design effective therapeutic agents for these diseases.

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