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Pattern of arterial calcification in patients with systemic lupus erythematosus
Journal of Rheumatology, 09/16/09

Yiu KH et al. – Patients with SLE have significantly higher prevalence and extent of systemic arterial calcification compared with age and sex matched controls

Methods

50 age and sex matched SLE patients and controls enrolled
64 slice MDCT scan to evaluate CS in coronary, carotid arteries and the aorta

Results

SLE patients had higher mean CS and prevalence of CS > 0 across all vascular beds
After adjustment for age and sex, SLE patient odds of having CS > 0 in any vascular bed was 33.6 (95% CI: 9.5–165.2) were higher versus patients in the control group, mainly due to more prevalent coronary calcification (OR 30.0, 95% CI: 6.7–203.8)
In SLE patients, the most frequent vessel with CS > 0 was coronary (42%) followed by carotid artery (24%)
Arterial calcification occurred early involving 40% of SLE patients at age < 40 years
Increasing prevalence as age advanced

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