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Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus
Journal of Rheumatology, 09/17/09

Soyfoo MS et al. – Serum levels of S100A8/A9 are significantly raised in SLE versus pSS patients and healthy controls and can be correlated to a disease activity index. S100A8/A9 is a more relevant marker of infection in SLE patients.

Methods

A group of 93 patients with SLE were studied over a period of 3 years, and 143 serum samples were analyzed
S100A8/A9 serum concentrations were determined by a sandwich ELISA
Sera from 10 primary Sjögren’s syndrome (pSS) patients and 50 healthy volunteers were used as controls
Correlations to SLEDAI, ANA, anti-dsDNA, WBC, CH50, C4, and CRP were made
In addition, infections were recorded in all SLE patients

Results

Serum levels of S100A8/A9 were significantly (p = 0.04) higher in SLE patients (1412 ± 664 ng/ml) versus healthy controls (339 ± 35 ng/ml) and pSS patients (400 ± 85 ng/ml)
The only significant correlation (r = 0.219; p = 0.015) was found was between S100A8/A9 and SLEDAI
Further, SLE patients with concomitant infections had higher serum levels of S100A8/A9 (39300 ± 13375 ng/ml) than those without infections (1150 ± 422 ng/ml)

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