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C-reactive protein gene polymorphisms in disease susceptibility and clinical manifestations of Korean systemic lupus erythematosus
Journal of Rheumatology, 09/16/09

Kim HA et al. – CRP gene –390 polymorphism plays a role in disease susceptibility of SLE through regulation of serum CRP level. Elevated basal CRP level may be important in the pathogenesis of SLE, even though CRP responsiveness to noninfectious inflammation of SLE is decreased.

Methods

Approximately 1.5 kb of CRP promoter region was screened for single nucleotide polymorphism (SNP) using direct sequencing and 3 SNP in CRP exons by restriction fragment length polymorphism
Basal levels of CRP measured by immunoturbidimetry
Effect of –390 C>A or T polymorphism on promoter activity was analyzed by luciferase reporter assay in Hep3B cells

Results

Allele frequency at polymorphisms within CRP promoter and exon in our Korean patients with SLE differed from Caucasians
A allele was a major allele at position 2043 in Korean SLE patients
G is a major allele in Caucasian SLE
Our SLE patients had minor allele in the –390 polymorphism more frequently versus controls
CRP 1185 polymorphism associated with thrombocytopenia
Basal levels of CRP were significantly higher in individuals who had minor allele in –390 and 2043 polymorphisms
Promoter-reporter construct carrying the –390 A or T allele displayed significantly higher promoter activity than that with the –390 C allele

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