Rheumatology Medical News about osteoarthritis;colon carcinoma;deleted

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Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration
Rheumatology, 09/14/09

Schubert T et al. – Strong differential expression of DCC in OA compared with normal chondrocytes indicates a possible role of DCC in the pathophysiology of OA. The strong impact of the DCC receptor on cellular mobility of chondrocytes suggests a major relevance of migratory activities in physiological and pathological conditions of cartilage.

Methods

Gene expression determined by quantitative RT–PCR and immunohistochemistry
Gene regulation by electro mobility shift assay and chromatin immunoprecipitation
Functional assays on migration and differentiation were done after cell treatment and transfection

Results

DCC was shown to be specifically up-regulated in OA
Up-regulation of DCC in OA chondrocytes may be mediated by the transcription factors Sox9 and AP-2
Netrin-1 was revealed to induce the migration of OA chondrocytes
Expression of DCC in healthy chondrocytes by transient transfection significantly induced cell migration and chemotaxis to Netrin-1
DCC expression had no influence on cell differentiation
Induction of MMP1 and -3 expression was observed

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